Aphorism 5: No one knows when Jesus is coming back or how long it will be before Jesus comes back, and so application of separation passages cannot be dependent on how close or far the return of Christ is.
The words are startlingly clear—“the Pope of Rome … is that antichrist, that man of sin, and son of perdition, that exalteth himself in the church against Christ, and all that is called God; whom the Lord shall destroy with the brightness of His coming.” This statement is found in The London Baptist Confession of Faith of 1689 (26.4) as well as in unmodified versions of the Westminster Confession of Faith (25.6). Currently most modern Presbyterians and Baptists using these confessions have changed the wording or do not enforce this section. However, some stalwarts still remain.
Let’s unfold the exegesis a bit. There are about a dozen passages of Scripture in play, and application has been made. The “man of sin [has been] revealed, the son of perdition” (2 Thess. 2:3, KJV). The “falling away” has occurred and the person bearing the title “the Pope of Rome” is the end time’s figure of the final antichrist (cf. 1 John 2:18). Of the 7 billion people on the planet currently, only one man or his successor can be the antichrist. There is now no possibility of salvation for some future pope, because he is the antichrist. And there is no point in continued exploration of the meaning of Daniel, Matthew 24, 1 and 2 Thessalonians, and Revelation on this issue.